Bipolar I and Bipolar II disorder are serious, highly prevalent psychiatric conditions affecting approximately 11 million adult Americans. These are chronic and debilitating conditions with an increased risk of suicide and are reported as some of the most costly mental disorders.
These disorders are characterized by recurrent episodes of mania or hypomania interspersed with episodes of major depression known as bipolar depression. Bipolar I and Bipolar II each represent about half of the overall population of patients with bipolar disorder.
Bipolar depression remains a significantly underserved medical need.
Bipolar depression is the most common clinical presentation of bipolar disorder. These episodes tend to last longer, are more difficult to treat, recur more often, and are also observed to have worse prognosis than the manic/hypomanic episodes. Bipolar depression remains a significantly underserved medical need, with only a few FDA-approved treatment options available.